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Hematopoietic system assessment

structures and functions of the hematopoietic system and its associated assessment. Understanding the fundamental structures and functions of the hematologic system will allow the healthcare professional to intervene effectively when a patient experiences a hematological disorder A basic knowledge of hematology is useful in clinical settings to evaluate the patient's ability to transport oxygen and carbon dioxide, maintain intravascular volume, coagulate blood, and combat infections. Assessment of the hematologic system is based on the patient's health history, physical examination, and results of diagnostic studies Chapter 41 Assessment of the Hematologic System M. Linda Workman Learning Outcomes Safe and Effective Care Environment 1. Verify that the patient has given informed consent for a bone marrow aspiration or biopsy. Health Promotion and Maintenance 2. Assess the patient's endurance in performing ADLs. 3. Perform a clinical health history and risk assessment fo

Nursing Assessment: Hematologic System Nurse Ke

Toxic effects on the hematopoietic system from pharmaceuticals or chemicals may occur from accidental or intentional overexposure, the latter invariably in preclinical safety assessment studies, or through idiosyncrasy. Accidental or occupational exposure may also occur with marketed compounds Hematopoietic System Hematology is the science of blood and blood forming tissues. It includes both cellular and non-cellular blood components. Blood is composed of two elements: • A liquid component known as plasma • The solid components, which are mainly erythrocytes, leukocytes, and thrombocyte Learn hematopoietic system assessment function with free interactive flashcards. Choose from 500 different sets of hematopoietic system assessment function flashcards on Quizlet

The hematopoietic system is responsible for the continuous production of highly specialized mature circulating blood cells. Due to its high metabolic and proliferative rate, and because the functions performed by blood cells are vital to an organism, this system is highly susceptible to direct and indirect xenobiotic-induced injury Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [9] [10] [11] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin)

Assessment of the Hematologic System Nurse Ke

  1. Study Flashcards On Chapter 27, 28 Med Surg Hematopoietic and Lymphatic System Function, Assessment, and Therapeutic Measures/Nursing Care of Patients with Hematological and Lymphatic Disorders at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want
  2. The hematopoietic system originates from the proliferation and differentiation of a rare population of cells named the hematopoietic stem cell (HSC). During development, HSC are located in different environments, from the aorta-gonade-mesonephros area in embryos, through the foetal liver in foetuses to the bone marrow (BM) in adults
  3. Chapter 31: Caring for Clients with Disorders of the Hematopoietic System. STUDY. Flashcards. Learn. Write. Spell. Test. PLAY. Match. Gravity. Created by. jmorden85. Terms in this set (46) A client with anemia has been admitted to the medical-surgical unit. Which assessment findings are characteristic of iron deficiency anemia? Dyspnea.
  4. It is also the study of the organs and tissues that use blood cells to perform their physiologic functions. These include the lymph nodes, the spleen, thymus, and other lymphoid tissue. The hematopathologist focuses on the diagnosis of conditions of the hematopoietic and lymphocyte-rich tissues
  5. Blood and the system that forms it, known as the hematopoietic system, consist of many cell types with specialized functions (see Figure 2.1). Red blood cells (erythrocytes) carry oxygen to the tissues. Platelets (derived from megakaryocytes) help prevent bleeding

The hematopoietic system, which comprises all the cellular components of the blood, is one of the earliest organ systems to evolve during embryo development. Hematopoietic stem cells (HSCs), which are rare blood cells residing in the bone marrow of the adult organism, are the founder cells that give rise to the entire hematopoietic system Chapter 79 Structure and Function of Hematopoietic Organs Seth J. Corey, Julie Blatt Pearls • Hematologic intervention is one of most frequent therapeutic modalities in the intensive care unit setting. • The blood system is frequently affected by severe illnesses, and its failure contributes to morbidity and mortality. • Normal ranges for blood cell number

Hematopoietic System - an overview ScienceDirect Topic

nursingbulletin.com :) hematologic system. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads Allogeneic HSCT provides a form of immune rescue for individuals with defects in their hematopoietic system, by enabling the regeneration of a healthy, donor-derived immune system following pretransplant radiochemotherapy conditioning regimens that partially or fully ablate the existing immune system. Assessment of immunological recovery.

hematopoietic system assessment function Flashcards and

  1. ation in hematopoietic system akk 1. 1 History Taking and Physical Exa
  2. Merck and the Merck Manuals. Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world
  3. Childhood hematopoietic cell transplantation involves the infusion of blood stem cells into a patient to reconstitute the blood system. Get detailed information about autologous and allogeneic transplant, HLA matching, preparative regimens, and complications in this summary for clinicians
  4. Accreditation requires you to attend the session as well as successfully completing the module assessment. Successful completion of the module will lead to awarding of two accreditations: Hematopoietic System Hematopoietic System: Infectious Occupational Diseases If you have already successfully completed the Stream 1 module and you want to.
  5. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potential curative treatment for both congenital and hematological malignancies. Immune reconstitution after allogeneic hematopoietic stem cell transplantation is implicated in successful transplant outcomes such as overall survival and relapse-free survival. The reconstitution of immune cell subsets after HSCT occurs in.
  6. The primary endpoints were the safety and efficacy assessment, measured as Adverse Reactions (ARs) incidence [according to World Health Organization - Uppsala Monitoring Centre (WHO-UMC) causality assessment system], rate of mortality within 28-days, and the time to clinical improvement of 2 points on a seven-category ordinal scale or discharge.
  7. system; hematopoietic system Ethylene glycol monoethyl ether acetate (111-15-9) ˜ 300 Development Ethylene glycol monomethyl ether (109-86-4) ˜ 60 Reproductive system Ethylene glycol monomethyl ether acetate (110-49-6) ˜ ˜ 90 Reproductive system Appendix D3 6 Table of value

Hematopoietic System - ScienceDirec

Abstract Evaluation of immunoprofile as predictive and prognostic biomarker are essential to follow up patients in Multiple Myeloma after autologous hematopoietic stem cells transplantation (AHSCT). It can be defining the engraftment and predicts complications Cellular Barcoding Tool for Clonal Analysis in the Hematopoietic System Blood. 2010 Apr 1;115(13):2610-8. doi: 10.1182/blood-2009 -06-229757 with transgene expression and integration site analysis. This cellular barcoding tool permits a simple, sensitive assessment of clonality and holds great promise for future gene therapy protocols in. Thus any problem of the hematologic system affects total body health and well-being. This chapter, together with Chapter 19, reviews the normal physiology of the hematologic system and assessment of hematologic status. FIG. 41-1 Role of the hematologic system in oxygenation and tissue perfusion. RBCs, Red blood cells hematopoietic system that are inherited, acquired, or result from myeloablative treatment. The risk benefit assessment for an individual patient depends on the patient characteristics, including.. View taking history hematopoietic .pptx from BIO 3100 #4 at Wayne State University. History Taking and Physical Examination of the Hematopoietic System 1 Assessment of a Patient in Hematology

Haematopoietic system - Wikipedi

Assessment of the blood profile is fundamental to any diagnostic workup, and this is particularly true for the hematopoietic system. Discover the world's research 20+ million member In general, for disorders that require replacement of an abnormally functioning hematopoietic system, such as thalassemia and aplastic anemia, an allogeneic transplant is performed. For young patients with severe aplastic anemia (SAA) who have a matched sibling donor, an allogeneic BMT is the standard therapy HEMATOPOIETIC SYSTEM Majuvy L. Sulse RN, MSN, CCRN Description Process of Formation & development of blood cells Begins in early embryonic stage & continuous thru - A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 4aa369-ZmRk World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Winner of the Standing Ovation Award for Best PowerPoint Templates from Presentations Magazine. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect Leukine (sargramostim) is a recombinant human granulocyte‐macrophage colony stimulating factor (rhu GM‐CSF) produced by recombinant DNA technology in a yeast (S. cerevisiae) expression system. GM‐CSF is a hematopoietic growth factor which stimulates proliferation and differentiation of hematopoietic progenitor cells

Different blood cells in the human body form through the hematopoietic process, which starts when an embryo is formed. Cells play a major role in the human body, especially the white blood cells, which fight infections throughout the body and are transported by the lymphatic system Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. This process occurs in the red bone marrow, in the core of most bones. In embryonic development, the red bone marrow is derived from the layer of the embryo called the mesoderm

Chapter 27, 28 Med Surg Hematopoietic and Lymphatic System

Healthy hematopoietic stem cells (HSCs) are capable to self-renew and reconstitute the complete hematopoietic system. Upon aging, there is an increased incidence of blood-related diseases. Age-related phenotypes have been widely studied by bone marrow transplantation experiments, where reconstitution of the transplanted cells is a direct. Hematopoietic progenitor cells (HPCs) or hematopoietic stem cells (HSCs) are cells present in blood and bone marrow. HPCs are capable of forming mature blood cells, such as red blood cells (the cells that carry oxygen), platelets (the cells that help stop bleeding) and white blood cells (the cells that fight infections)

Hematopoietic and Lymphatic System Function,Assessment, and Therapeutic Measures, Understanding Medical Surgical Nursing 3rd - Linda S. Williams, Paula D. Hopp Our Discord hit 10K members! Meet students and ask top educators your questions The hematopoietic cell transplantation-comorbidity index (HCT-CI) is a comorbidity tool suited for recipients of HCT. The index has been shown to sensitively capture the prevalence and magnitude of severity of various organ impairments before HCT and to provide valuable prognostic information after HCT As the whole body or partial body dose from external exposure increases, the severity of the hematopoietic subsyndrome of ARS increases. Physical dosimeters worn over clothing can estimate/record dose from exposure, but during a mass casualty incident, it is unlikely that most members of the general public will be wearing physical dosimeters Culture assays can be used to examine the ability of hematopoietic stem and progenitor cells to proliferate and differentiate in response to hematopoietic growth factors and to study their interactions with stromal cells of the hematopoietic microenvironment

Isolation of bone marrow cells, including hematopoietic stem cells, is a commonly used technique in both the research and clinical settings. A quantitative and qualitative assessment of cell populations isolated from mouse and human bone marrow was undertaken with a focus on the distribution of hematopoietic cells between the central bone marrow (cBM) and endosteal bone marrow (eBM) The hematopoietic system is responsible for the production of the cellular blood components including B cells, T cells, macrophages, neutrophils, and megakaryocytes, all of which play crucial roles in normal and disease processes . The entire hematopoietic system undergoes constant turnover throughout life through the self-renewal and. [15][16] Also, regeneration after allogeneic hematopoietic SCT (HSCT) has been associated with accelerated telomeric shortening. [16][17][18] However, long-term assessment of telomere length (TL) after HSCT has shown inconsistent results regarding the degree and persistence of telomere shortening

1 INTRODUCTION. Hematopoietic stem cells (HSCs) are immature multipotent adult stem cells that give rise to all mature blood cell lineages, demonstrate long‐term engraftment, and are able to hierarchically reconstitute the entire hematopoietic system in a conditioned recipient after infusion Hematopoietic stem cells (HSC) are characterized with the capacity for self-renewal as well as multi-lineage differentiation, maintaining the immune system and blood cell formation throughout life. Although studies for the HSC biology have been in the assessment of pluripotency as well as self-renewal of human hematopoietic progenitors in. This course provides a foundation for the assessment and nursing management of infants with infectious processes. Review of laboratory tests and findings will be reviewed in addition to review of the hematopoietic system. Hyperbilirubinemia, polycythemia, disseminated intravascular coagulation and Rh/ABO incompatibilities will be presented

Abstract Background Previous studies of a cohort of rubber hydrochloride workers indicated an association between benzene exposure and excess mortality from leukemia and multiple myeloma. To determ.. Hematopoietic stem cells (HSCs) must exhibit tight regulation of both self-renewal and differentiation to maintain homeostasis of the hematopoietic system as well as to avoid aberrations in growth that may result in leukemias or other disorders Assessment of Human Multi-Potent Hematopoietic Stem/Progenitor Cell Potential Using a Single In Vitro Screening System, PLOS ONE, 2012, Volume 7, Issue 11, DOI: 10.1371/journal.pone.0050495 Home Abou The hematopoietic system is the most dynamic organ system in the human body. All hematopoietic or blood cell lineage develop within the bone marrow microenvironment and each cell type is groomed toward maturation within the niches of the bone marrow by exposure to specific growth factors and cytokines, as well as cell-to-cell and cell-to-stroma.

The NCD for Allogeneic Hematopoietic Stem Cell Transplantation (allo HSCT) for the treatment of Myelodysplastic Syndromes (MDS), released by CMS in August 2010, concluded that, absent convincing evidence that allo HSCT improves patient health outcomes, additional research from clinical trials would be appropriate under the Coverage with Evidence Development aspect of CMS' coverage authority The hematopoietic system represents a unique dynamic organization in which short-term living cells, with diverse properties and functions, require continuous production from a pool of hematopoietic stem/progenitor cells (HSPCs), mainly resident in the bone marrow (BM) during adult life. IS analyses have the potential to allow the assessment. HSCT refers to transfer of hematopoietic stem and progenitor cells derived from either the patient (autologous) or a donor (allogeneic) with the aim of repopulating and/or replacing the hematopoietic system either partially or in total 1,3; allogeneic and autologous HSCT is potentially curative for many disorders, including 1,2,3. hematologic malignancies (leukemias, lymphomas, multiple myeloma

Three hematopoietic cell sources are used in HCT: bone marrow, peripheral blood stem cells (PBSC), and umbilical cord blood. Each source in an allogeneic transplant can come from a related or unrelated donor or cord blood unit. Most autologous transplants use PBSC for ease of collection of the cells and a more rapid hematopoietic recovery daily life, others are severe and require more definitive treatment, such as a hematopoietic stem cell transplantation (HSCT). This chapter describes the types of PI that may require HSCT as treatment, or for which HSCT is a consideration, depending on the assessment of an individual patient's risks and benefits

Ch27

The Effect of High LET Radiation on Differentiation and Tumorigenesis in the Human Hematopoietic System: Modeling in vitro and in vivo for Risk Assessment Risk of Radiation Carcinogenesis Cancer-302: Identify tissue-specific surrogate end-points for space radiation induced pre-malignancy and shared biology with other degenerative diseases For hematopoietic homing assessment, 10 6 young or aged WBM cells, with or without 5 × 10 5 young (3 months old) ECs, were infused or coinfused into young (3 months old) lethally irradiated (9.50 Gy) CD45.1 + (B6.SJL-Ptprc a Pepc b /BoyJ) recipients. Femurs and spleens were removed 16 hours after infusion, flushed with PBS (pH 7.2) containing.

In the past 20 years, hematopoietic stem cell transplantation (HSCT) has been investigated as treatment for systemic sclerosis (SSc). The goal of HSCT is to eradicate the autoreactive immune system, which is replaced by a new immune repertoire with long-lasting regulation and tolerance to autoantigens. Here, we describe the clinical outcomes of severe and refractory SSc patients that underwent. In this article, Forsberg and colleagues use quantitative reconstitution assays to demonstrate that all myeloid-competent progenitor cells also contribute to erythroid and platelet production. Single-cell in vivo analyses showed that hematopoietic stem cells and multipotent progenitors are clonally multipotent. These results suggest that erythropoiesis is a default hematopoietic fate and. Hematopoietic stem cell transplantation (HSCT) involves the intravenous (IV) infusion of autologous or allogeneic stem cells to reestablish hematopoietic function in patients whose bone marrow or immune system is damaged or defective. The image below illustrates an algorithm for typically preferred hematopoietic stem cell transplantation cel..

PPT - Hematologic System, Oncologic Disorders & Anemias Dr(PDF) Role of physical therapy pre and post hematopoietic

Module X - Nutrients involved in the Hematopoietic System 6. Vitamin K d. Groups at risk 1) People with fat malabsorption 2) Infants - born with a sterile GIT (usually given injection at birth) 3) People taking large amounts or for a long time of non absorbable antibiotics e. Dietary sources 1) Bacterial synthesis in large intestine 2) Liver, green vegetables, milk e The risk benefit assessment for an individual patient depends on the patient characteristics, including disease, stage, risk factors, and specific manifestations of the disease, on characteristics of the graft, and on other available treatments or types of hematopoietic progenitor cells. Dose & HLA matchin

Chapter 25- Blood Cells and the Hematopoietic SystemExam #3 Review

The NCD for Stem Cell Transplantation Multiple Myeloma (MM), Myelofibrosis (MF) and Sickle Cell Disease (SCD), released by CMS on January 27, 2016, concluded that, CMS will cover items and services necessary for research under §1862(a)(1)(E) for a allogeneic hematopoietic stem cell transplant (HSCT) for certain Medicare beneficiaries with myelofibrosis (MF) using the Coverage with Evidence. Subchronic and chronic exposures to benzene vapors induce a progressive depletion of the bone marrow and dysfunction of the hematopoietic system. Early symptoms of bone marrow depression include leukopenia, anemia or thrombocytopenia, or a combination of the three (Snyder, 1984) Date Manual Section Add/Remove/Modify Description ; 3/9/2021 : 2006: Hematopoietic Stem Cell Transplant (HCT) InfusionAdd : Product Processing blue note box added above question 33: Product Processing: Wash and dilution, both which generally apply to cord blood units, are now included as processing options, though they may not be classified as such by laboratories The lymphatic system, or lymphoid system, is an organ system in vertebrates that is part of the circulatory system and the immune system.It is made up of a large network of lymph, lymphatic vessels, lymph nodes, lymphatic or lymphoid organs, and lymphoid tissues. The vessels carry a clear fluid called lymph (the Latin word lympha refers to the deity of fresh water, Lympha) towards the heart Objective: Hematopoietic syndrome (HS) is a clinical diagnosis assigned to people who present with ≥1 new-onset cytopenias in the setting of acute radiation exposure. The World Health Organization convened a panel of experts to evaluate the evidence and develop recommendations for medical countermeasures for the management of HS in a hypothetical scenario involving the hospitalization of 100.

stem-cells-fig-2 - Dimensions of Dental Hygiene

Viral Genes: Assessment of Transduction and Toxicity in Human Hematopoietic Cells Hartmut Stecher, Dmitry M. Shayakhmetov, George Stamatoyannopoulos, and André Lieber* Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA *To whom correspondence and reprint requests should be directed With the extensive utilization of radioactive materials for medical, industrial, agricultural, military, and research purposes, medical researchers are trying to identify new methods to treat acute radiation syndrome (ARS). Radiation may cause injury to different tissues and organs, but no single drug has been proven to be effective in all circumstances. Radioprotective agents are always. At present, allogeneic hematopoietic stem-cell transplantation is the only curative option. 3-5 Approximately 200 children have undergone this procedure after myeloablative conditioning with.

Hematopoietic system: Hemolytic anemia, hyperplasia of hematopoietic tissue, decreased hemoglobin and hematocrit values, and hemolytic anemia were reported in animals orally exposed to copper. Hemolytic anemia is also one of the effects seen in patients with Wilson's disease The LTC system was originally developed for primitive progenitors of the myeloid (i.e., granulocyte, macrophage, erythroid and megakaryocyte) lineages. 24, 25 It was subsequently adapted to support the growth of B lymphoid and NK cell progenitors. 26, 27 LTC assays are performed by culturing hematopoietic cells on an adherent monolayer of. Here we are with a hematopoietic and lymphatic system quiz! The blood in our body plays a significant role in ensuring oxygen is transported to the organs, has components that protect the body from harm, and at the same time, gets rid of waste materials. Do you know how the blood components are made and using which organs play what part? Take the quiz and get to see how these two systems are.

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.This process is called haematopoiesis. This process occurs in the red bone marrow, in the core of most bones.In embryonic development, the red bone marrow is derived from the layer of the embryo called the mesoderm.. Haematopoiesis is the process by which all mature blood cells are produced Leuk Res 1999;23:239. Pizzuto-Chavez J, Mayani H. Hematopoietic progenitor cells from [27] Podesta M, Piaggio G, Frassoni F. The assessment of the patients with myelodysplastic syndromes: in vitro colony-growth hematopoietic reservoir after immunosuppressive therapy or bone and long-term proliferation Overview. Hematopoietic cell transplantation (HCT) involves the infusion of hematopoietic progenitor cells into patients with malignant or nonmalignant hematologic disorders with the goal of re-establishing normal hematopoietic and immune function. 1,2 HCT is a potentially curative treatment option for patients with certain types of hematologic malignancies and is also used to support patients. Hematopoietic growth factors. Hematopoiesis is the process by which our bodies make red blood cells, white blood cells, and platelets. The process is regulated in part by hematopoietic growth factors—naturally occurring hormones that stimulate the proliferation and differentiation of hematopoietic stem cells, and enhance function in the mature forms of those cells

Assessment of Human Multi-Potent Hematopoietic Stem

Hematopoietic System Structure and Function ° Importance of the hemapoietic system o Provides nutrients that allow organs to live and function normally. treat pain; reassure client that frequent assessment can prevent complications ° Hemophilia - chronic hereditary disease, body lacks one or more clotting factor Megakaryocyte lineage commitment in the hematopoietic system is known to be influenced by signal transduction events in hematopoietic stem and progenitor cells initiated by binding of thrombopoietin (TPO) to its receptor cMPL [14-16].TPO was identified in 1994 by a number of groups by virtue of its ability to rescue cMPL‐dependent cell lines.

Chapter 31: Caring for Clients with Disorders of the

Hodgkin Disease. Medically Necessary: An allogeneic (ablative and non-myeloablative) or autologous hematopoietic stem cell transplantation is considered medically necessary for individuals with primary refractory Hodgkin disease or Hodgkin disease that has relapsed after an initial first remission (regardless of remission status at the time of transplant) Define hematopoietic. hematopoietic synonyms, hematopoietic pronunciation, hematopoietic translation, English dictionary definition of hematopoietic. also he·mo·poi·e·sis n. Related to hematopoietic: hematopoietic system, hematopoietic A new report titled Global Hematopoietic Stem Cell Transplantation Market Industry Assessment.

Nuclear Factor Erythroid 2 Regulates Human HSC SelfExtramedullary hematopoiesis in a case of benign mixedHepatic Veno-occlusive Disease (Sinusoidal ObstructionPPT - Chapter 20: The Healthy Newborn PowerPoint

(Picker and Siegelman, 1999). Since the hematopoietic sys-tem is a potential target organ of chemical exposure, evalu-ation of the blood and bone marrow is an important compo-nent of toxicity or safety assessment studies. As part of the hematopoietic system evaluation, morphological assessment of bone marrow tissue sections provides information. ASSESSMENT OF MUTATION BURDEN IN HEMATOPOIETIC STEM CELL CLONES AS A RESULT OF AGING AND INFLAMMATORY STRESS. Author(s): we have used a genetic label-retention system to segregate dormant and actively cycling HSCs in order to assess whether mutations are predominantly acquired during replication.. Hematopoietic Syndrome General The hematopoietic syndrome, sometimes referred to as the bone marrow syndrome, is produced by acute whole body doses of approximately 200 to 800 rads (2 - 8 Gy). Some authors place the range at 100 to 1000 rads and others specify the upper end of the range low as 600 rads. 25 py pp Figure 7 A model of EC contributions to development of the hematopoietic system in mammals. Show full caption. ECs contribute directly to hematopoiesis by giving rise to hematopoietic stem/progenitor cells (HSPCs) via endothelial-hematopoietic transition (EHT). In addition, ECs generate BMSCs that establish the hematopoietic niche via EndoMT. Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing. Zhaojun Zhang 1, Haibo Jia 2, Qian Zhang 1, Yang Wan 3, Yang Zhou 2, Qiong Jia 2, Wanguang Zhang 4, Weiping Yuan 3, Tao Cheng 3, Xiaofan Zhu 3 & Xiangdong Fang

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